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Tags: accurate mass, breast cancer, breast cancer test, breast cancer tissue, diagnostic assays, epidermal growth factor, epidermal growth factor receptor, gaithersburg md, growth factor receptor, laser microdissection, maryland technology, mass spectrometry techniques, patient treatment decisions, protein analysis, protein assays, proteomics technologies, quantitative assay, quantitative test, technology development corporation, tissue biopsy,
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Created: Thu Feb 7 09:50:17 2008
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                                    FOR IMMEDIATE RELEASE

Expression Pathology Obtains Maryland Funding to Develop Breast Cancer Test

Gaithersburg, MD. February 6, 2008: Expression Pathology Inc. (EPI), a leader in tissue protein analysis,
has obtained $125,000 from the State of Maryland to develop a quantitative test for HER2 protein, an
important biomarker in breast cancer tissue samples. The funding is part of the Maryland Technology
Development Corporation's Maryland Technology Transfer Fund (TEDCO MTTF) and the Maryland
Venture Fund's Challenge Investment Program.

Using proprietary tissue processing technologies, EPI is developing a quantitative assay for HER2 (human
epidermal growth factor receptor 2) in breast cancer. EPI's Liquid Tissue® reagents and DirectorTM laser
microdissection slides are used to extract proteins from standard formalin-fixed tissue. These proteins are
then analyzed by highly accurate mass spectrometry techniques. Current methods of analysis that rely on
visual interpretation of staining patterns in tissue have been found to have limitations, according to several
recent articles and studies.

"This funding comes at a critical point in Expression Pathology's development," said Casey Eitner, EPI's
president and chief executive officer. "Our tissue proteomics technologies have already been adopted by
major academic and industrial customers for research use. We believe that diagnostic assays utilizing mass
spectrometry for tissue analysis have the potential to greatly improve patient treatment decisions, especially
in cancer, where tissue biopsy and surgery are routine. "New quantitative tissue protein assays for analytes
such as HER2 will be of tremendous interest for cancer research, but will also have wide application in
clinical trials and patient diagnostics," Mr. Eitner continued. "This funding will accelerate our program to
develop a better HER2 assay. We are grateful to the State of Maryland for having these funding programs to
support innovative, early-stage commercialization initiatives."

According to the American Association for Cancer Research, approximately 40,000 women are diagnosed
annually in the U.S. with HER2-positive breast cancer.

About Expression Pathology Inc.
Formalin-fixed and paraffin-embedded (FFPE) tissue samples are routinely collected and stored in medical
treatment and research facilities. They constitute a huge untapped resource for discovery, validation and
accurate measurement of biomarkers of disease progression and recurrence, drug response and toxicity.

Expression Pathology's Liquid Tissue® reagents and DirectorTM laser microdissection slides are opening
new ways to extract valuable protein information from FFPE tissue, and could provide the foundation for a
new generation of clinical research and diagnostic tools. For more information, visit
www.expressionpathology.com.

Contact
Peter Tunon
Vice President, Sales and Marketing, Expression Pathology
(301) 977-3654
p.tunon@expressionpathology.com