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National Institutes of Health Summary of the FY 2009 President's…

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National Institutes of Health

Summary of the FY 2009 President's Budget




                                     February 4, 2008
National Institutes of Health FY 2009 President's Budget                                            2



                                       NIH Budget at a Glance

                                        National Institutes of Health
                                             ( dollars in millions)


                                                                                     Change from
                                           FY 2007         FY 2008      FY 2009        FY 2008
                                            Actual         Enacted      Estimate       Enacted
  Labor/HHS Discretionary
    Budget Authority (B.A.)                   $28,899        $29,230       $29,230             $0
  Interior B.A.                                   $79            $78           $78             $0
  Total Discretionary B.A.                    $28,978        $29,307       $29,307             $0
  Type I Diabetes Initiative                     $150           $150          $150             $0
  Total B. A.                                 $29,128        $29,457       $29,457             $0
  NIH Program Level                           $29,137        $29,465       $29,465             $0
  AIDS Program                                 $2,906         $2,913        $2,913             $0
  Number of Competing RPGs                     10,323          9,771         9,757            -14
  Total Number of RPGs                         38,845         38,239        38,257             18
  Success Rate                                   21%            19%           18%            -1%
  FTEs                                         16,997         17,138        17,254          +116


The FY 2009 Discretionary Budget Authority request for the NIH is $29,230 million, equal to
the FY 2008 appropriation. The total NIH budget authority with the Type I Diabetes Initiative
for FY 2009 is $29,380 million. It provides a total Program Level in FY 2009 of $29,465
million, the same as the FY 2008 Enacted Level.

The FY 2009 Request maintains the AIDS research program at the FY 2008 level of $2,913
million. In addition, NIH will provide $300 million to the Global Fund for HIV/AIDS,
Tuberculosis and Malaria.

NIH has modified its traditional budget display by mechanism so that activities of the National
Cancer Institute's Cancer Prevention and Control Program and the National Library of Medicine
are allocated among the various trans-NIH mechanisms of support.


Moving Towards Medicine in 2030

Fifty years ago, a man died instantly from a heart attack. Twenty five years ago, his son
experienced chest pains and received a bypass operation. This year, his grandson was diagnosed
with high cholesterol and is on statins. What does the future hold for his great-grandson? Over
the years, through discoveries from basic research, population studies, and clinical research, we
have moved from--doing nothing about heart disease, to relying largely on invasive surgeries,
such as coronary bypass, to prevention through the use of blood pressure and cholesterol-
National Institutes of Health FY 2009 President's Budget                                        3

lowering drugs. We have cut the deaths from heart disease by 50% over the last 30 years, but
can we take the next step to predict or preempt the development of heart disease? Can we
improve treatment so that it is most effective and personalized?

In the past 40 years, NIH funded research has successfully reduced the mortality and morbidity
of once acute and lethal conditions by finding ways to improve treatment -- even in late stages.
These advances have helped change the landscape of disease from acute to chronic diseases,
which now form the largest component of health burden. Biomedical research is the key to
transform medicine from the curative health care paradigm of the past where we intervened late
in the natural history of a disease, to a preemptive model in which the onset of disease is
significantly delayed or even never allowed to develop.

Based on the progress and discoveries made through NIH-supported research just in the last few
years, NIH can foresee its vision of a future and transformative era of medicine and health care
that is increasingly predictive, personalized and preemptive. This era will include more active
participation by individuals and communities in their own care. Support for NIH will increase
our ability to explore and understand the fundamental causes of disease at the earliest molecular
stages and allow us to expand the ability to predict a disease before it develops. As we expand
the knowledge of individual genetic differences and response to environment we will increase
our ability to implement individually targeted or personalized treatment. Ultimately, this
research should allow us to preempt disease before it occurs. Finally, critical components of this
new revolutionary approach to 21st century medicine will result in greater participation of
individuals, communities and healthcare institutions

Our vision for this future is emerging from NIH-funded researchers across the nation, as well as
the thousands of scientists and laypersons from whom the NIH solicits input through our study
sections and advisory councils. History demonstrates no one can predict where the next great
discovery or life-saving breakthrough will occur. Therefore, NIH employs a robust system to
inspire bright minds to propose their best and most innovative ideas to tackle current and
emerging public health problems. The proposals undergo a rigorous peer review process and
only those with most promise receive support. On occasion, NIH management takes a more
active role to stimulate research in a pressing area like bioterrorism countermeasures or
pandemic influenza. However, the workhorse of NIH research is the investigator-initiated
project. These projects consistently provide discoveries that make Americans healthier and
provide a training ground for the highly skilled individuals who work in the nation's
pharmaceutical, biotechnology, and academic career fields. The Nation's return on investment
in NIH is demonstrated by improved health for the Nation and this investment has strengthened
the Nation's competitiveness and its economy.

US health expenditures continue to grow far faster than general inflation. Investments in NIH
have lead to progress in the fight against heart disease, cancer, and AIDS, among many others,
and have helped save lives and avoid unnecessary health expenditures. At NIH, we believe
health care costs will not be tempered unless we accelerate the discovery of transformative ways
of practicing medicine ­ which can only happen through research.
National Institutes of Health FY 2009 President's Budget                                             4


In the FY 2009 budget request, we have identified the following strategic priorities:

Support New Investigators ­ We will continue to nurture a vibrant, creative research
workforce, and include sufficient numbers of new investigators with new ideas and new skills in
areas such as interdisciplinary research. In FY 2007, we set a goal to sustain 1500 new
investigators each year-- based on the NIH five year historical average. We exceeded this goal.
To help ensure the pipeline of future investigators is maintained as the current workforce ages
and begins to retire, we plan to continue support for the Pathway to Independence program with
another 170 awards. In FY 2009, the Pathway program will support approximately 500
awardees at a total of $71 million. In FY 2009 we will also support approximately 25 New
Innovator Awards, for a total of $56 million in the NIH Common Fund.

NIH Director's Bridge Award -- The FY 2009 Request level includes $91.2 million to continue
the NIH Director's Bridge Award program, to protect our investment in well-established and
meritorious investigators with little or no other significant support.

NIH Common Fund ­ We plan continued support for the Common Fund in FY 2009 with a
program level of $534 million, an increase of $38 million over the FY 2008 Enacted Level. The
Common Fund is an incubator for new ideas and initiatives that will accelerate the pace of
discovery. These initiatives are focused on efforts that no single or small group of Institutes or
Centers could conduct on their own, and have potential to transform biomedical and behavioral
research.

The second cohort of initiatives in the Common Fund was launched in FY 2007, and continues
into FY 2008 and FY 2009. The two new program areas that began preparatory studies and
projects in FY 2007 include projects in the 1) Human Microbiome--a project to characterize the
microbial content of sites in the human body and their relationship to disease and the
environment; and 2) Epigenomics--the study of stable genetic modifications and their
relationship to disease. Funds are identified in the FY 2009 Common Fund for the continuation
of these projects. In addition, the FY 2009 request has reserved up to $46 million for new
projects that will be developed during FY 2008. NIH will also continue the New Innovator
Awards, at a level of $56 million.
National Institutes of Health FY 2009 President's Budget                                                           5

                                 FY 2009 President's Budget Request
                                     Total NIH Budget Authority
                                           $29,457 Million


                                                                       Research Centers
      Research Project Grants                                               10.1%
              52.7%
                                                                                          Other Research
                                                                                              6.1%


                                                                                               Research Training
                                                                                                     2.7%




                                                                                                R&D Contracts
                                                                                                   11.1%


                                                                                    Intramural Research
                                                                                          10.6%
                                                           Res. Mgmt. & Support
                                                                  4.6%
                                         All Other
                                           2.2%




Mechanism Discussion

Research project grants (RPGs) are the primary mechanism for funding of investigator-initiated
biomedical research; therefore, support for RPGs remains a high priority in the FY 2009
President's Budget. This will enable NIH to maintain support for ongoing research and to
support new researchers and new ideas to maintain the vitality of biomedical research.

Inflationary pressure on our research portfolio and scientific purchasing power remains a key
concern; however, we have made the difficult decision to again eliminate inflationary increases
for RPGs. While no inflationary increases are provided for direct, recurring costs in non-
competing RPG's in the FY 2009 President's Budget, where the NIH has committed to a
programmatic increase in an award, such increases will be provided. The average cost of
competing RPGs will remain at the FY 2008 level.

In the FY 2009 President's Budget, NIH proposes to increase support for research centers to
$2,963 million, a 0.7% increase above the FY 2008 Enacted Level. This request level will
continue to provide program growth for the Clinical and Translational Science Awards (CTSAs).

Support for Other Research decreases by $23 million, or 1.3%. NIH will fund a third cohort of
researchers in the Pathway to Independence program, with around 170 awards for $15 million.
Also in FY 2009, the 1st cohort of Pathway awards "graduate" into noncompeting RPGs. Total
support for the Pathway program in FY 2009 is $71 million and over 500 recipients. The
National Institutes of Health FY 2009 President's Budget                                        6
Roadmap program, Nanomedicine Centers, will continue to use the Flexible Research Authority
of $25 million, the same amount as FY 2008.

In order to achieve the NIH's research objectives, it is essential to ensure that highly trained
scientists will be available to address the nation's biomedical, behavioral and clinical research
needs. Pre-doctoral fellows, who currently receive $20,772, have not seen a stipend increase
since FY 2004. Post-doctoral fellows, who begin at $36,996, have not seen a stipend increase
since FY 2006 (for 0 to 1 year of experience only). In the FY 2009 President's Budget, NIH
proposes modest stipend increases of 1% for both pre- and post-doctoral fellows. At the FY 2009
President's Budget level, NIH will support 17,586 Full-Time Training Positions (FTTPs), an
increase of 17 FTTPs over the FY 2008 level. It is important to ensure the pipeline of future
investigators is adequate as the current workforce ages and begins to retire. NRSA funding
increases by $5 million or 0.6% over the FY 2008 Enacted Level.

R&D contracts increase by $33 million and 1% compared to the FY 2008 Enacted Level. This
increase includes $5 million in additional funds for the Global Fund for HIV/AIDS, Tuberculosis
and Malaria to other high-priority NIH research programs. Total support for the Global Fund in
FY 2009 is $300 million.

In the FY 2009 Submission, support for the NIH intramural research program would increase by
1.6% above the FY 2008 Enacted Level, for a total of $3,119 million. This increase maintains the
intramural program at approximately 11% of NIH's overall budget.

For FY 2009, RMS would be funded at $1,361 million, an increase of $20 million and 1.5%
above the FY 2008 Enacted Level, enabling appropriate administration of NIH resources. This
will provide NIH with sufficient capacity to manage its research portfolios, and to ensure
appropriate stewardship of all funds.
National Institutes of Health FY 2009 President's Budget                                                    7



                                             FY 2009 NIH Request
                                 Percent Change From Selected FY 2008 Enacted
                                             Budget Mechanisms


                                                           -

        7.5%

        5.5%

        3.5%
                                                                         1.0%         1.6%         1.5%
                                0.7%                           0.6%
        1.5%       -0.1%                     -1.3%


       -0.5%
               Research     Research      Other       Research          R&D       Intramural   Res. Mgmt.
                Project      Centers     Research     Training        Contracts    Research    & Support
                Grants




The OD decreases by $52 million and 5%. The FY 2009 Request includes $91.2 million for the
NIH Director's Bridge Award program. No funds are provided for the National Children's
Health Study.

The FY 2009 Request Level for B&F is $133.4 million. Of this amount, $7.8 million would be
provided to the National Cancer Institute (NCI) for repairs and improvements at the NCI-
Frederick campus. The B&F appropriation request of $125.6 million provides for essential-only
Repairs and Improvements, a modest amount for concept development studies and essential
safety and regulatory compliance.
National Institutes of Health FY 2009 President's Budget                                                                                       8
                                                    NATIONAL INSTITUTES OF HEALTH
                                                         Summary of Appropriations
                                                            (Dollars in millions)

                                                             FY 2007 Budget                     FY 2008             FY 2009
                  Appropriation                               Authority 1/ 2/                 Enacted 1/ 2/        Estimate 2/     2009/2008
                                                              Includes AIDS                 Includes AIDS         Includes AIDS    $ Change
 NCI                                                                      4,795                          4,805             4,810            5
 NHLBI                                                                    2,919                          2,922             2,925            3
 NIDCR                                                                      390                             390              391            0
 NIDDK 2/                                                                 1,856                          1,857             1,858            2
 NINDS                                                                    1,535                          1,544             1,545            1
 NIAID 3/                                                                 4,366                          4,561             4,569            8
 NIGMS                                                                    1,936                          1,936             1,938            2
 NICHD                                                                    1,254                          1,255             1,256            1
 NEI                                                                        667                             667              668            1
 NIEHS                                                                      642                             642              643            1
 NIA                                                                      1,047                          1,047             1,048            1
 NIAMS                                                                      508                             509              509            0
 NIDCD                                                                      394                             394              395            1
 NIMH                                                                     1,404                          1,405             1,407            1
 NIDA                                                                     1,000                          1,001             1,002            1
 NIAAA                                                                      436                             436              437            0
 NINR                                                                       137                             137              138            0
 NHGRI                                                                      486                             487              488            1
 NIBIB                                                                      298                             299              300            2
 NCRR                                                                     1,144                          1,149             1,160           11
 NCCAM                                                                      121                             122              122            0
 NCMHD                                                                      199                             200              200            0
 FIC                                                                         66                              67               67            0
 NLM                                                                        320                             321              323            3
 OD                                                                       1,047                          1,109             1,057          -52
 B&F                                                                         81                             119              126            7
 Type 1 Diabetes                                                           -150                           -150              -150            0
 Subtotal, Labor/HHS                                                     28,899                         29,230            29,230            0
 Interior Approp. for Superfund Res.                                         79                              78               78             0
  Total, NIH Discretionary B.A.                                          28,978                         29,307            29,307            0
 Type 1 Diabetes                                                            150                             150              150             0
 Total, NIH Budget Authority                                             29,128                         29,457            29,457            0
 NLM Program Evaluation
 ONDCP                                                                          - 8                        - 8              - 8               0
 Total, Prog. Level                                                          29,137                     29,465           29,465               0
 Totals may not add due to rounding

 1/ Includes comparable program transfers
 2/ Includes funds for the Type 1 Diabetes Initiative.
 3/ Includes funds to be transferred to the Global Fund for HIV/AIDS, Malaria, and Tuberculosis.
National Institutes of Health FY 2009 President's Budget                                                                                                   9
                                                       NATIONAL INSTITUTES OF HEALTH
                                                                Budget Mechanism - Total
                                                                     (Dollars in millions)
                                                             FY 2007                       FY 2008                      FY 2009
                MECHANISM                                    Actual 1/                     Enacted                      Estimate                  Change
Research Grants:                                    No.           Amount           No.         Amount           No.          Amount         No.      Amount
Research Projects:
 Noncompeting                                     26,741             $11,005     26,728            $11,194    26,759           $11,169         31        -$25
 Administrative supplements                       (1,633)                205     (1,684)               195    (1,776)              214       (92)          19
 Competing                                        10,323               3,788      9,771              3,534     9,757             3,520       (14)         -14
     Subtotal, RPGs                               37,064              14,998     36,499             14,923    36,516            14,903         17         -20
SBIR/STTR                                          1,781                 629      1,740                620     1,741               620          1           0
   Subtotal, RPGs                                 38,845              15,627     38,239             15,543    38,257            15,523         18         -20
Research Centers:
 Specialized/comprehensive                          1,193              2,238      1,150              2,225     1,155             2,231          5              6
 Clinical research                                     88                381         88                418        72               423        -16              5
 Biotechnology                                        109                137        106                124       102               124         -4              0
 Comparative medicine                                  54                124         54                122        60               131          6              9
 Research Centers in Minority Institutions             28                 54         28                 54        28                54          0              0
    Subtotal, Centers                               1,472              2,934      1,426              2,943     1,417             2,963         -9             20
Other Research:
 Research careers                                  4,293                 663      4,451                688     4,449               685         -2           -3
 Cancer education                                     89                  31         89                 32        89                32          0            0
 Cooperative clinical research                       435                 425        427                425       427               425          0            0
 Biomedical research support                         188                  98        143                 64       144                64          1            0
 Minority biomedical research support                165                 111        161                110       161               110          0            0
 Other                                             1,756                 465      1,726                490     1,706               470        -20          -20
    Subtotal, Other Research                       6,926               1,793      6,997              1,809     6,976             1,786        -21          -23
 Total Research Grants                            47,243              20,354     46,662             20,295    46,650            20,272        -12          -23

Ruth L. Kirschstein Training Awards:             FTTPs                           FTTPs                        FTTPs
 Individual awards                                 2,982                   121     2,997                122     3,004                 124      7               2
 Institutional awards                             14,614                   661    14,572                660    14,582                 663     10               3
 Total, Training                                  17,596                   782    17,569                782    17,586                 787     17               5

Research & development contracts                    2,895              2,985      2,886              3,242     2,913             3,275        27           33
   (SBIR/STTR)                                        (98)               (26)      (106)               (29)     (106)              (29)       (0)          (0)

Intramural research                                                    3,035                         3,069                       3,119                       50
Research management and support                                        1,317                         1,341                       1,361                       20
Extramural Construction                                                   14                             0                           0                        0
                                                                                                                                                              0
Office of the Director                                                   473                           524                          432                     -92
  (Appropriation)                                                     (1,047)                       (1,109)                     (1,057)                  (-52)
Buildings and Facilities 1/                                               89                           127                          133                       6
  (Appropriation)                                                        (81)                         (119)                       (126)                     (7)
NIH Roadmap for Medical Research*                                       (483)                         (496)                        (534)                   (38)
Type 1 Diabetes 2/                                                       -150                          -150                         -150                      0
Subtotal, Labor/HHS Budget Authority                                  28,899                        29,230                      29,230                       0
Interior Appropriation for Superfund Res.                                 79                            78                           78                       0
Total, NIH Discretionary B.A.                                         28,978                        29,307                      29,307                        0
Type 1 Diabetes 2/                                                        150                           150                          150                      0
Total, NIH Budget Authority                                            29,128                        29,457                      29,457                       0
NLM Program Evaluation                                                      8                             8                            8                      0
Total, Program Level                                                  29,137                        29,465                      29,465                        0

May not add due to rounding
*Included in above mechanisms.
1/ Includes the B&F appropriation plus the following included in NCI -- FY 06: $7.9M; FY 07: $7.9M; FY 08: $7.8M.
2/ Included in NIDDK -- FY 07: $150M; FY 08: $150M; FY 00: $150M for Type I Diabetes Initiative.
Numbers of grants identified in FY 2008 and FY 2009 are estimates, and WILL change as applications are
received and selected for funding.
NIH has modified its traditional budget display by mechanism so that activities of the National Cancer Institute's Cancer Prevention and Control Program and
the National Library of Medicine are allocated among the various trans-NIH mechanisms of support.