Information about http://www.urotoday.com/prod/pdf/reviews/bju2_aug2006.pdf

Review Article STEPS TO BETTER HEALTH FOR MEN KIRBY et al. Steps…

Tags: amoroso, better health, cardiovascular disease, cultural beliefs, gap, gender gap, gould, insufficient exercise, john dean, longevity, male patients, men s health, mortality and morbidity, physical behaviour, prostate centre, roger s kirby, type 2 diabetes, unhealthy patterns, urologist, weight exercise,
Pages: 4
Language: english
Created: Wed Jun 28 06:43:18 2006
Display cached document
Page 1
image
Page 2
image
Page 3
image
Page 4
image
Review Article
STEPS TO BETTER HEALTH FOR MEN
KIRBY
 et al.




Steps by which better overall health for men could
be achieved
ROGER S. KIRBY, MIKE G. KIRBY*, PETER AMOROSO, JOHN DEAN and DUNCAN GOULD
The Prostate Centre, London and *The Surgery, Letchworth, UK
Accepted for publication 2 March 2006



INTRODUCTION                                                        world's populations. The UK shows a pattern                             a programme of exercise and healthy
                                                                    similar to that first seen in the USA, about                            nutrition.
Men's health has become an important                                half of adults in Britain are now estimated
medical, social and political issue. On average,                    to be at an unhealthy weight [2]. This is
men die 5 years younger than women, and                             probably the result of cultural beliefs,                                EXERCISE
some reasons for this `gender gap' are deeply                       insufficient exercise, combined with an
entrenched and unhealthy patterns of male                           unbalanced proportion of calories/energy                                It is now widely accepted that regular physical
behaviour. In this review, we set out ways by                       consumed vs energy expended. Weight                                     exercise can reduce an individual's age-
which the urologist can interact positively                         gain can be subtle and insidious, increasing                            adjusted risk of mortality and morbidity from
with their male patients to increase their                          gradually over a long time, and is deleterious                          cardiovascular disease (CVD), hypertension,
longevity and enhance their quality of life [1].                    for overall health.                                                     stroke, type 2 diabetes, osteoporosis and some
                                                                                                                                            cancers, while often improving lipid profiles
Currently, most men are very reluctant to                           Obesity is estimated to shorten life by an                              [4­7]. Much research suggests that the
make the adjustments that contribute to a                           average of 9 years, i.e. 2 years more than                              improvements are greatest, especially for
healthy lifestyle. Too often, they allow                            prostate cancer. In the UK, 6% of all deaths                            cardiovascular health, when an individual is
themselves to develop central obesity and                           can be attributed to obesity. Being overweight                          exercising at their optimum level. This
thereby lay themselves open to all the                              increases a man's risk of developing type 2                             requires physical exertion of sufficient
features of the metabolic syndrome (Fig. 1).                        diabetes, high blood pressure, and several                              intensity to achieve 50­85% of one's
They visit the doctor on average only half as                       cancers (prostate included) as well as likely                           maximum heart rate, sustained for 30 min/
often as women, and then only when                                  disturbances in lipid levels. It also increases                         day, for 5 days/week. However, many
symptoms serve as a `wake-up call'. Often, the                      the likelihood of osteoarthritis of the knees,                          individuals are very averse even to the
first symptom that encourages them to                               hips and ankles, back pain and swelling of the                          thought of such strenuous activity. As any
accept a check-up is urological, e.g. urinary                       legs. Although many people who are obese                                exercise is better than none, and the health of
frequency, urgency/flow problems, or                                consume too many calories, their diet is often                          today's sedentary adults might be improved
anxieties about sexual, especially erectile,                        deficient in the nutrients essential for good                           with relatively low levels of physical activity.
dysfunction (ED). Evaluation may reveal                             health. A balanced diet includes three regular                          For some of these men, enthusiasm for
underlying prostate disease, obesity, diabetic                      meals a day, providing lots of fruit, vegetables,                       exercise and health improvement can be
tendency and/or hypertension, as well as                            whole-grains and less saturated fat. Recent                             achieved simply by incorporating leisure
significant dyslipidaemia. At this stage there                      studies showed that, in patients aged 70­90                             activities, e.g. walking, gardening, cycling, or
is a risk that the urinary symptoms and/or ED                       years, adherence to a Mediterranean-type                                golf, which can be gradually increased over
might be treated purely symptomatically, with                       diet and healthy lifestyle lowered all-cause                            time to include gym work or swimming [8].
an -blocker or phosphodiesterase type 5                             and cause-specific mortality by more than                               Specifically, buying a pedometer and walking
inhibitor, thereby missing a crucial                                half [3].                                                               5­10 000 steps/day can be both inspiring and
opportunity to address the associated risk                                                                                                  motivational. In addition to the physical
factors and lifestyle issues.                                       Excessive eating is just one example of                                 benefits, exercise is likely to have positive
                                                                    conditioning and habituation that could be                              psychological effects. The recent paper by
All healthcare professionals dealing with men                       described as an `addiction'. A pharmacological                          Giovannucci et al. [9], which reported that
on a daily basis, but especially a team which                       addiction that is much more difficult to break                          men aged >65 years who engaged in vigorous
focuses on urological health, are well placed                       is smoking. Hectoring about the hazards of                              exercise for >3 h/week reduced their risk of
to work with the patient and his partner to                         smoking is unlikely to result in a durable                              high-grade, advanced or fatal prostate cancer
increase life-expectancy and enhance quality                        cessation of the habit. Hypnotherapy can                                by 70%, might provide the impetus for
of life. Outlined below are some ways by                            work for some, as can the application of                                urologists, cardiologists and others to
which this could be achieved.                                       willpower and cognitive techniques. The use                             emphasize the benefits of exercise to their
                                                                    of nicotine replacement (skin patches, gum                              patients.
                                                                    and inhalants, etc.), used for at least 3 months
HEALTHY EATING AND                                                  while cravings abate, is far more likely to
STOPPING SMOKING                                                    achieve the results that both the physician                             SEXUAL HEALTH
                                                                    and patient desire. Stopping smoking is often
In the past 30 years, the prevalence of weight                      associated with weight gain, which can be                               Up to 52% of men aged 40­70 years will
gain and obesity has increased in many of the                       helped by counselling and strict adherence to                           have experienced some degree of ED [10].


©     2006 THE AUTHORS
JOURNAL COMPILATION              ©   2 0 0 6 B J U I N T E R N A T I O N A L | 9 8 , 2 8 5 ­ 2 8 8 | doi:10.1111/j.1464-410X.2006.06221.x                                              285
K I R BY ET AL.



International research suggests that ED             LDL cholesterol levels should be lowered to        DIABETES
affects 20% of men, and in 1995 it was              60 years [16]. The WHO has
way of increasing physical activity, helping to     defined a `normal' blood pressure as a systolic    Diabetes is currently estimated to cost 9% of
relieve stress and deepen a relationship, and it    blood pressure of 15 million deaths per year             that the metabolic syndrome might be              CONFLICT OF INTEREST
worldwide. The UK has one of the highest               associated with hypogonadism in men
rates of CVD in the world. Although the UK is          [21], and there is a high prevalence of           Dr Duncan Gould undertakes consultancy
behind most other countries in preventing              hypogonadism in men with diabetes. Most of        work for AstraZeneca.
and treating CHD, numbers are falling, by              the differences in testosterone levels between
3000 deaths/year. Common risk factors for              men with diabetes and men without diabetes
CVD include an unhealthy diet (high in                 might be due to low levels of sex-hormone-        REFERENCES
saturated fat), inactivity, smoking, excess            binding globulin. Free testosterone levels fall
alcohol consumption, high blood pressure,              with increasing age and obesity, making many      1   Kirby RS, Kirby MG, Carson C, Farah R
high blood cholesterol, and diabetes. Many of          men with type 2 diabetes testosterone-                eds, Men's Health, 2nd edn. London:
these risk factors can be eliminated or at least       deficient. Testosterone replacement might             Taylor & Francis, 2004
ameliorated. However, some people might                improve insulin sensitivity in hypogonadal,       2   Campbell I. The obesity epidemic: can we
have a genetic predisposition to the disease,          overweight men [22].                                  turn the tide? Heart 2003; 89 (Suppl. 2):
and if these are identified, precautionary                                                                   ii22­4
steps, e.g. lifestyle modification and the use of      Therefore, hypogonadism appears to be an          3   Knoops KT, de Groot LC, Kromhout D
statins, can be implemented.                           important component of the metabolic                  et al. Mediterranean diet, lifestyle factors,
                                                       syndrome. It is interesting to consider that          and 10-year mortality in elderly European
HYPOGONADISM AND THE                                   testosterone therapy might not only treat             men and women: the HALE Project. JAMA
METABOLIC SYNDROME                                     hypogonadism, but might also slow or halt             2004; 292: 1433­9
                                                       the progression from metabolic syndrome to        4   Powell KE, Thompson PD, Caspersen CJ,
The metabolic syndrome is characterized                overt diabetes and eventually CVD, through            Kendrick JS. Physical activity and the
by central obesity, insulin resistance,                its beneficial effects on insulin regulation,         incidence of coronary heart disease. Ann
dyslipidaemia and hypertension (Fig. 1). It is         lipid profile and blood pressure [23]. In             Rev Public Health 1987; 8: 253­87
very prevalent in all westernised countries,           addition, in men, the use of testosterone to      5   Shinton R, Sagar G. Lifelong exercise and
and significantly increases the risk of diabetes       treat the metabolic syndrome might also               stroke. BMJ 1993; 307: 231­4


©   2006 THE AUTHORS
JOURNAL COMPILATION        ©    2006 BJU INTERNATIONAL                                                                                               287
K I R BY ET AL.



6    Helmrich SP, Ragland DR, Leung RW,            14 Baigent C, Keech A, Kearney PM et al.,            projections for 2030. Diabetes Care 2004;
     Paffenbarger RS Jr. Physical activity            Cholesterol Treatment Trialists' (CTT)            27: 1047­53
     and reduced occurrence of non-insulin            Collaborators. Efficacy and safety of        21   Makhsida N, Shah J, Yan G, Fish H,
     dependent diabetes mellitus. N Engl J Med        cholesterol-lowering treatment:                   Shabsigh R. Hypogonadism and the
     1991; 325: 147­52                                prospective meta-analysis of data from            metabolic syndrome: implications for
7    Wood PD, Staphanick ML, Williams                 90,056 participants in 14 randomized              testosterone therapy. J Urol 2005; 174:
     PT, Haskell WL. The effects on plasma            trials of statins. Lancet 2005; 366: 1267­        827­34
     lipoproteins of prudent weight-reducing          78                                           22   Betancourt-Albrecht M, Cunningham
     diet, with or without exercise, in            15 Shannon J, Tewoderos S, Garzotto M                GR. Hypogonadism and diabetes. Int J
     overweight men and women. N Engl J Med           et al. Statins and prostate cancer risk: a        Impot Res 2003; 15 (Suppl. 4): S14­S20
     1991; 325: 461­6                                 case control study. Am J Epidemiol 2005;     23   Simon D, Charles MA, Lahlou N et al.
8    MacAuley D. Benefits and Hazards of              162: 318­25                                       Androgen therapy improves insulin
     Exercise. London: BMJ Books, 1999             16 Nawrot T, Den Hond E, Thijs L, Staessen           sensitivity and decreases leptin level in
9    Giovannucci EL, Liu Y, Leitzmann MJ,             JA. Isolated systolic hypertension and the        healthy adult men with low plasma total
     Stampfer MJ, Willett WC. A prospective           risk of vascular disease. Curr Hypertens          testosterone: a 3-month randomised,
     study of physical activity and incident and      Rep 2003; 5: 372­9                                placebo-controlled trial. Diabetes Care
     fatal prostate cancer. Arch Intern Med        17 Petrie JR, Kirby M. Too much of a                 2001; 24: 2149­51
     2005; 165: 1005­10                               good thing: 2004 Guidance from               24   Wahrenberg H, Hertel K, Leijohufvud
10   Feldman HA, Goldstein I, Hatzichristou           NICE and BHS-IV on hypertension in                BM, Persson LG, Toft E, Arner P. Use of
     DG, Krane RJ, McKinlay JB. Impotence             diabetes. Br J Diabetes Vasc Dis 2004;            waist circumference to predict insulin
     and it's medical and psychosocial                4: 365­8                                          resistance: retrospective study. BMJ 2005;
     correlates: results of the Massachusetts      18 Chobanian A, Bakris GL, Black HR et al.,          330: 1363­4
     Male Aging Study. J Urol 1994; 151: 54­          National High Blood Pressure                 25   Kirby RS. The urologist as the advocate of
     61                                               Education Program Coordinating                    men's health. BJU Int 2005; 95: 929
11   Dunn KM, Croft PR, Hackett GI. Sexual            Committee. Seventh report of the Joint       26   Vasan RS, Pencina MJ, Cobain M,
     problems: a study of the prevalence              National Committee on Prevention,                 Freiberg MS, D'Agostino RB. Estimated
     and need for health care in the general          Detection, Evaluation and Treatment of            risks for developing obesity in the
     population. Fam Pract 1998; 15: 519­24           High Blood Pressure: the JNC 7 report..           Framingham Heart Study. Ann Intern Med
12   Greenstein A, Chen J, Miller H, Matzkin          JAMA 2003; 289: 2560­72                           2005; 143: 473­80
     H, Villa Y, Braf Z. Does severity of          19 Moore LL, Visioni AJ, Qureshi MM,
     ischemic coronary heart disease correlate        Bradlee ML, Ellison RC, D'Agostino R.        Correspondence: Roger S. Kirby, The Prostate
     with erectile dysfunction? Int J Impot Res       Weight loss in overweight adults and the     Centre, 32 Wimpole St, London W1G 8GT, UK.
     1997; 9: 123­6                                   long-term risk of hypertension: the          e-mail: bjui@theprostatecentre.com
13   Jackson G, Betteridge J, Dean J et al.           Framingham study. Arch Intern Med 2005;
     A systemic approach to erectile in the           165: 1298­303                                Abbreviations: ED, erectile dysfunction; CHD,
     cardiovascular patient: a consensus           20 Wild S, Roglic G, Green A, Sicree R,         coronary heart disease; CVD, cardiovascular
     statement. Int J Clin Pract 1999; 53: 445­       King H. Global prevalence of diabetes:       disease; (L)(H)DL, low-density (high-density)
     51                                               estimates for the year 2000 and              lipoprotein.




                                                                                                                            ©   2006 THE AUTHORS
288                                                                                         JOURNAL COMPILATION      ©   2006 BJU INTERNATIONAL